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The Candida albicans gene for mRNA 5-cap methyltransferase: identification of additional residues essential for catalysis.

Microbiology (Reading, England) - 1 Nov 1999

Yamada-Okabe Toshiko, Mio Toshiyuki, Kashima Yuji, Matsui Mitsuaki, Arisawa Mikio, Yamada-Okabe Hisafumi

Abstract excerpt

The 5'-cap structure of eukaryotic mRNA is methylated at the terminal guanosine by RNA (guanine-N7-)-methyltransferase (cap MTase). Saccharomyces cerevisiae ABD1 (ScABD1) and human hMet (also called CMT1) genes are responsible for this enzyme. The ABD1 homologue was cloned from the pathogenic fungus Candida albicans and named C. albicans ABD1 (CaABD1). When expressed as a fusion with glutathione S-transferase...

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PMID: 10589710
DOI: 10.1099/00221287-145-11-3023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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