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Article

mRNA capping enzyme requirement for Caenorhabditis elegans viability.

The Journal of biological chemistry - 18 Apr 2003

Srinivasan Priya, Piano Fabio, Shatkin Aaron J

Abstract excerpt

Capping of the initiated 5' ends of RNA polymerase II products is evolutionarily and functionally conserved from yeasts to humans. The m(7)GpppN cap promotes RNA stability, processing, transport, and translation. Deletion of capping enzymes in yeasts was shown to be lethal due to rapid exonucleolytic degradation of uncapped transcripts or failure of capped but unmethylated RNA to initiate protein synthesis. Using...

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PMID: 12576475
DOI: 10.1074/jbc.M212102200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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