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Article

Single allele knock-out of Candida albicans CGT1 leads to unexpected resistance to hygromycin B and elevated temperature.

Microbiology (Reading, England) - 1 Feb 2000

De Backer Marianne D, de Hoogt Ronald A, Froyen Guy, Odds Frank C, Simons Fermin, Contreras Roland, Luyten Walter H M L

Abstract excerpt

Almost all eukaryotic mRNAs are capped at their 5'-terminus. Capping is crucial for stability, processing, nuclear export and efficient translation of mRNA. We studied the phenotypic effects elicited by depleting a Candida albicans strain of mRNA 5'-guanylyltransferase (mRNA capping enzyme; CGT1). Construction of a Cgt1-deficient mutant was achieved by URA-blaster-mediated genetic disruption of one allele of the...

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Identifiers

PMID: 10708374
DOI: 10.1099/00221287-146-2-353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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