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Article

Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997

Yue Z, Maldonado E, Pillutla R, Cho H, Reinberg D, Shatkin A J

Abstract excerpt

5'-Capping is an early mRNA modification that has important consequences for downstream events in gene expression. We have isolated mammalian cDNAs encoding capping enzyme. They contain the sequence motifs characteristic of the nucleotidyl transferase superfamily. The predicted mouse and human enzymes consist of 597 amino acids and are 95% identical. Mouse cDNA directed synthesis of a guanylylated 68-kDa...

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Identifiers

PMID: 9371772
DOI: 10.1073/pnas.94.24.12898
PMCID: PMC24235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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