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Article

Can an arbitrary sequence evolve towards acquiring a biological function?

Journal of molecular evolution - 1 Feb 2003

Hayashi Yuuki, Sakata Hiroshi, Makino Yoshihide, Urabe Itaru, Yomo Tetsuya

Abstract excerpt

To explore the possibility that an arbitrary sequence can evolve towards acquiring functional role when fused with other pre-existing protein modules, we replaced the D2 domain of the fd-tet phage genome with the soluble random polypeptide RP3-42. The replacement yielded an fd-RP defective phage that is six-order magnitude lower infectivity than the wild-type fd-tet phage. The evolvability of RP3-42 was...

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Identifiers

PMID: 12574862
DOI: 10.1007/s00239-002-2389-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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