Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of phage with chemically ambiguous proteomes.

BMC evolutionary biology - 10 Dec 2003

Bacher Jamie M, Bull James J, Ellington Andrew D

Abstract excerpt

BACKGROUND: The widespread introduction of amino acid substitutions into organismal proteomes has occurred during natural evolution, but has been difficult to achieve by directed evolution. The adaptation of the translation apparatus represents one barrier, but the multiple mutations that may be required throughout a proteome in order to accommodate an alternative amino acid or analogue is an even more daunting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome, Viral
Share to Bacteriophages
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amino Acid Substitution

Share to Molecular Sequence Data

Share to Proteome

Share to Tryptophan

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 14667253
DOI: 10.1186/1471-2148-3-24
PMCID: PMC317279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of phage with chemically ambiguous proteomes.PMID 14667253Read ↗

Mistranslation: from adaptations to applications.Semantic proximity Read ↗

The 'evolvability' of promiscuous protein functions.Semantic proximity Read ↗

Non-adaptive complexity and biochemical function.Semantic proximity Read ↗

Genetic code ambiguity: an unexpected source of proteome innovation and phenotypic diversity.Semantic proximity Read ↗

Insertions and deletions in protein evolution and engineering.Semantic proximity Read ↗

Can an arbitrary sequence evolve towards acquiring a biological function?Semantic proximity Read ↗

Rules for designing protein fold switches and their implications for the folding codeSemantic proximity Read ↗

Simple evolutionary pathways to complex proteins.Semantic proximity Read ↗

Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins.Semantic proximity Read ↗

Creative destruction: New protein folds from old.Semantic proximity Read ↗

Microbial manipulation of the amyloid foldSemantic proximity Read ↗

Destabilizing mutations encode nongenetic variation that drives evolutionary innovation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.