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Article

Evolution of an arbitrary sequence in solubility.

Journal of molecular evolution - 1 Feb 2004

Ito Yoichiro, Kawama Toshihiro, Urabe Itaru, Yomo Tetsuya

Abstract excerpt

We have investigated the evolvability of an insoluble random polypeptide, RP3-34, to a soluble form through iterative mutation and selection with the aid of the green fluorescent protein (GFP) folding reporter. To assess the solubility of the polypeptides in the selected clones of each generation...

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Identifiers

PMID: 15042340
DOI: 10.1007/s00239-003-2542-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15042340-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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