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Article

Systematic molecular evolution enables robust biomolecule discovery.

Nature methods - 1 Jan 2022

DeBenedictis Erika A, Chory Emma J, Gretton Dana W, Wang Brian, Golas Stefan, Esvelt Kevin M

Abstract excerpt

Evolution occurs when selective pressures from the environment shape inherited variation over time. Within the laboratory, evolution is commonly used to engineer proteins and RNA, but experimental constraints have limited the ability to reproducibly and reliably explore factors such as population diversity, the timing of environmental changes and chance on outcomes. We developed a robotic system termed phage- and...

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PMID: 34969982
DOI: 10.1038/s41592-021-01348-4
PMCID: PMC11655129

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