Article
TP53 mutations in human meningiomas.
The International journal of biological markers - 1 Jan 2000
Verheijen F M, Sprong M, Kloosterman J M E, Blaauw G, Thijssen J H H, Blankenstein M A
Abstract excerpt
Overexpression of p53 has been reported to play a role in the development of neoplasms of the central nervous system. Meningiomas are generally benign intracranial tumors originating from the meninges. Overexpression of the p53 protein in meningiomas and an association with histological type and recurrence has been reported. Mutation of the TP53 gene leads to a more stable p53 protein in quantities high enough...
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