Molecular changes during the genesis of human gliomas.

doi:10.1002/(sici)1098-2388(199801/02)14:1<3::aid-ssu2>3.0.co;2-f

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Article

Molecular changes during the genesis of human gliomas.

Seminars in surgical oncology - 1 Jan 2000

Sehgal A

Abstract excerpt

Neoplastic transformation in the normal human brain occurs as a result of the accumulation of a series of genetic alterations. These genetic alterations include the loss, gain or amplification of different chromosomes which lead to altered expression of proteins that play important roles in the r...

Topics

Brain Neoplasms
Cell Transformation, Neoplastic
Chromosome Deletion
Chromosomes, Human
Gene Deletion
Gene Expression Regulation
Glioma
Humans
Mutation

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