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Article

The role of germline BRCA1 & BRCA2 mutations in familial pancreatic cancer: A systematic review and meta-analysis.

PloS one - 1 Jan 2024

Limijadi Edward Kurnia Setiawan, Muniroh Muflihatul, Prajoko Yan Wisnu, Tjandra Kevin Christian, Respati Danendra Rakha Putra

Abstract excerpt

BACKGROUND: Familial Pancreatic Cancer (FPC) presents a notable risk, with 3-10% of pancreatic adenocarcinoma cases having a family history. Studies link FPC to syndromes like HBOC, suggesting BRCA1/BRCA2 mutations play a role. BRCA gene functions in DNA repair impact FPC management, influencing sensitivity to therapies like PARP inhibitors. Identifying mutations not only aids FPC treatment but also reveals...

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Identifiers

PMID: 38809921
DOI: 10.1371/journal.pone.0299276
PMCID: PMC11135687

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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