Article
BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2015
Zhen David B, Rabe Kari G, Gallinger Steven, Syngal Sapna, Schwartz Ann G, Goggins Michael G, Hruban Ralph H, Cote Michele L, McWilliams Robert R, Roberts Nicholas J, Cannon-Albright Lisa A, Li Donghui, Moyes Kelsey, Wenstrup Richard J, Hartman Anne-Renee, Seminara Daniela, Klein Alison P, Petersen Gloria M
Abstract excerpt
PURPOSE: Familial pancreatic cancer kindreds contain at least two affected first-degree relatives. Comprehensive data are needed to assist clinical risk assessment and genetic testing. METHODS: Germ-line DNA samples from 727 unrelated probands with positive family history (521 met criteria for familial pancreatic cancer) were tested in compliance with the Clinical Laboratory Improvement Amendments for mutations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.