Article
Linkage of mild malaria to the major histocompatibility complex in families living in Burkina Faso.
Human molecular genetics - 15 Feb 2003
Flori Laurence, Sawadogo Serge, Esnault Christelle, Delahaye Nicolas Frédéric, Fumoux Francis, Rihet Pascal
Abstract excerpt
Tumor necrosis factor alpha (TNF alpha) is thought to be a critical mediator of malaria fever, and mild malaria was previously reported to be linked to the MHC region containing the tumor necrosis factor alpha gene (TNF). Thirty-four families from Burkina Faso were analyzed to test for linkage between polymorphisms within the MHC region and mild malaria using the maximum-likelihood-binomial (MLB) program....
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