Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs.

doi:10.1136/bmj.315.7100.96

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Article

Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs.

BMJ (Clinical research ed.) - 12 Jul 1997

Jepson A, Sisay-Joof F, Banya W, Hassan-King M, Frodsham A, Bennett S, Hill A V, Whittle H

Abstract excerpt

Case-control studies have indicated that genes for the major histocompatibility complex influence the presentation and outcome of severe Plasmodium falciparum disease. To assess the role of genetic factors in mild malaria, an analysis was conducted in 217 pairs of Gambian twins (mean age, 5.3 yea...

Topics

Alleles
Child, Preschool
Gambia
Genes, MHC Class II
Genetic Linkage
Histocompatibility Testing
Humans
Malaria
Polymorphism, Restriction Fragment Length
Risk

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