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Article

5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics.

ACS chemical neuroscience - 17 Aug 2022

Schmitz Gavin P, Jain Manish K, Slocum Samuel T, Roth Bryan L

Abstract excerpt

Serotonin (5-hydroxytryptamine; 5-HT) 2A receptor (5-HT2AR) signaling is essential for the actions of classical psychedelic drugs. In this study, we examined whether sequence variations in the 5-HT2AR gene affect the signaling of four commonly used psychedelic drugs. We examined the in vitro pharmacology of seven non-synonymous single-nucleotide polymorphisms (SNPs), which give rise to Ser12Asn, Thr25Asn,...

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Identifiers

PMID: 35894503
DOI: 10.1021/acschemneuro.1c00815

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