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Article

Functional SNPs in genes encoding the 5-HT2A receptor modify the affinity and potency of several atypical antipsychotic drugs.

Biological research for nursing - 1 Jan 2011

Davies Marilyn A, Conley Yvette, Roth Bryan L

Abstract excerpt

Atypical antipsychotic drugs (AADs) are the standard treatment for both the acute and long-term management of schizophrenia and an augmentation to mood stabilizers for bipolar disorder (BD). Yet many individuals who take AADs do not fully respond to them, while others experience side effects that include weight gain and metabolic disorder. This in vitro pharmacogenetic study examined whether allelic variants in...

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Identifiers

PMID: 20097665
DOI: 10.1177/1099800409358760

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