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Article

Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection.

Antimicrobial agents and chemotherapy - 1 Oct 2017

Yamada Kageto, Saito Ryoichi, Muto Saori, Kashiwa Machiko, Tamamori Yoshiko, Fujisaki Shingo

Abstract excerpt

Moraxella catarrhalis causes respiratory infections. In this study, fluoroquinolone-resistant strains were selected in vitro to evaluate the mechanism of fluoroquinolone resistance. Strains with reduced fluoroquinolone susceptibility were obtained by stepwise selection in levofloxacin, and fluoroquinolone targets gyr and par were sequenced. Six novel mutations in GyrA (D84Y, T594dup, and A722dup), GyrB (E479K and...

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Identifiers

PMID: 28760904
DOI: 10.1128/AAC.01336-17
PMCID: PMC5610493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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