Article
Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans.
EBioMedicine - 1 Sept 2015
Shadoud Lubana, Almahmoud Iyad, Jarraud Sophie, Etienne Jérôme, Larrat Sylvie, Schwebel Carole, Timsit Jean-François, Schneider Dominique, Maurin Max
Abstract excerpt
BACKGROUND: Infectious diseases are the leading cause of human morbidity and mortality worldwide. One dramatic issue is the emergence of microbial resistance to antibiotics which is a major public health concern. Surprisingly however, such in vivo adaptive ability has not been reported yet for many intracellular human bacterial pathogens such as Legionella pneumophila. METHODS: We examined 82 unrelated patients...
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