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Article

Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila.

Antimicrobial agents and chemotherapy - 1 Mar 2017

Descours Ghislaine, Ginevra Christophe, Jacotin Nathalie, Forey Françoise, Chastang Joëlle, Kay Elisabeth, Etienne Jerome, Lina Gérard, Doublet Patricia, Jarraud Sophie

Abstract excerpt

Monitoring the emergence of antibiotic resistance is a recent issue in the treatment of Legionnaires' disease. Macrolides are recommended as first-line therapy, but resistance mechanisms have not been studied in Legionella species. Our aim was to determine the molecular basis of macrolide resistance in L. pneumophila Twelve independent lineages from a common susceptible L. pneumophila ancestral strain were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28069647
DOI: 10.1128/AAC.02188-16
PMCID: PMC5328525

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