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Article

New insights into inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3.

Retrovirology - 24 Oct 2013

Wu Chengxiang, Nerurkar Vivek R, Lu Yuanan

Abstract excerpt

BACKGROUND: Host cellular tRNA(Lys3) is exclusively utilized by human immunodeficiency virus type 1 (HIV-1) as a primer for the replication step of reverse transcription (RTion). Consequently, the priming step of HIV-1 RT constitutes a potential target for anti-HIV-1 intervention. Previous studies indicated that a mutant tRNA(Lys3) with 7-nucleotide substitutions in the 3' terminus resulted in aberrant HIV-1...

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Identifiers

PMID: 24156557
DOI: 10.1186/1742-4690-10-112
PMCID: PMC3832253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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