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Article

On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genome.

Nucleic acids research - 1 Sept 2003

Huthoff Hendrik, Bugala Katarzyna, Barciszewski Jan, Berkhout Ben

Abstract excerpt

Initiation of reverse transcription is a complex and regulated process in all retroviruses. Several base pairing interactions have been proposed to occur between the HIV-1 RNA genome and the specific tRNA(lys3) primer. The tRNA primer can form up to 21 bp with the primer binding site (PBS), and an additional 8 bp interaction may form between the primer activation signal (PAS) in the HIV-1 RNA and sequences within...

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Identifiers

PMID: 12930970
DOI: 10.1093/nar/gkg714
PMCID: PMC212812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genome.PMID 12930970Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS.Semantic proximity Read ↗

Initiation of HIV-1 Reverse Transcription Is Regulated by a Primer Activation SignalSemantic proximity Read ↗

Initiation of HIV-2 reverse transcription: a secondary structure model of the RNA-tRNA(Lys3) duplex.Semantic proximity Read ↗

Does the HIV-1 primer activation signal interact with tRNA3(Lys) during the initiation of reverse transcription?Semantic proximity Read ↗

Efficient extension of a misaligned tRNA-primer during replication of the HIV-1 retrovirus.Semantic proximity Read ↗

New insights into inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3.Semantic proximity Read ↗

Efficient initiation of HIV-1 reverse transcription in vitro. Requirement for RNA sequences downstream of the primer binding site abrogated by nucleocapsid protein-dependent primer-template interactions.Semantic proximity Read ↗

Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.Semantic proximity Read ↗

Forced selection of tRNA(Glu) reveals the importance of two adenosine-rich RNA loops within the U5-PBS for SIV(smmPBj) replication.Semantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

Primer tRNA3Lys on the viral genome exists in unextended and two-base extended forms within mature human immunodeficiency virus type 1Semantic proximity Read ↗

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