Article
p73 gene mutations in gastric adenocarcinomas.
Molecular pathology : MP - 1 Feb 2003
Pilozzi E, Talerico C, Platt A, Fidler C, Ruco L
Abstract excerpt
BACKGROUND/AIMS: The p73 gene encodes a protein that shares structural and functional homology with the p53 gene product. The highest degree of homology is in the DNA binding domain, which is the region of p53 that is most frequently mutated in cancer. In contrast to p53 there is little evidence that p73 acts as a classic tumour suppressor gene. Because of the similarities between the p53 and p73 genes and the...
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