Article
A case-control study on the effect of p53 and p73 gene polymorphisms on gastric cancer risk and progression.
Mutation research - 30 Apr 2009
De Feo Emma, Persiani Roberto, La Greca Antonio, Amore Rosarita, Arzani Dario, Rausei Stefano, D'Ugo Domenico, Magistrelli Paolo, van Duijn Cornelia M, Ricciardi Gualtiero, Boccia Stefania
Abstract excerpt
The p53 protein and its functional homologue p73 share several functions in modulating cell-cycle control and apoptosis. Based on the functional interaction between p53 and p73 in carcinogenesis, we investigated the combined effect of p73 G4C14-to-A4T14 and p53 gene polymorphisms and their interaction with selected environmental factors, on the risk for gastric cancer in a hospital-based case-control study...
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