Article
Mutational analysis of p73 and p53 in human cancer cell lines.
Oncogene - 3 Jun 1999
Yoshikawa H, Nagashima M, Khan M A, McMenamin M G, Hagiwara K, Harris C C
Abstract excerpt
p73 is a candidate tumor suppressor gene with substantial DNA and protein homology to the p53 tumor suppressor gene. We have investigated two hypotheses: (a) p73 is mutated in diverse types of human cancer, and (b) p73 is functionally redundant with p53 in carcinogenesis so that mutations would be exclusive in these two genes. The entire coding region and intronic splice junctions of p73 were examined in 54...
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