Article
Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype.
International journal of cancer - 8 Oct 1999
Yokozaki H, Shitara Y, Fujimoto J, Hiyama T, Yasui W, Tahara E
Abstract excerpt
To establish the possible involvement of p73, a newly discovered p53-related candidate as a tumor-suppressor gene in human stomach carcinogenesis, the allelic status, allele-specific expression and mutations of the gene were investigated using PCR-restriction fragment length polymorphism (PCR-RFLP) analysis, RT-PCR SSCP analysis and direct DNA sequencing in 95 gastric adenocarcinomas. Of these, 32 exhibited the...
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