Article
Variations in the human CC chemokine eotaxin gene.
Genes and immunity - 1 Dec 2001
Miyamasu M, Sekiya T, Ohta K, Ra C, Yoshie O, Yamamoto K, Tsuchiya N, Tokunaga K, Hirai K
Abstract excerpt
The CC chemokine eotaxin (CCL11) plays a major role in the recruitment and activation of eosinophils in allergic disorders. In the present study, we performed polymorphism screening of the coding and promoter regions of the eotaxin gene (SCYA11). A G to A single nucleotide substitution was detected at position 67, which resulted in a non-conservative amino acid change of Ala at position 23 to Thr (A23T) within...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.