Article
Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway.
PloS one - 1 Jan 2017
Ehm Margaret G, Aponte Jennifer L, Chiano Mathias N, Yerges-Armstrong Laura M, Johnson Toby, Barker Jonathan N, Cook Suzanne F, Gupta Akanksha, Hinds David A, Li Li, Nelson Matthew R, Simpson Michael A, Tian Chao, McCarthy Linda C, Rajpal Deepak K, Waterworth Dawn M
Abstract excerpt
A phenome-wide association study of variants in genes in the Th17 and IL-17 pathway was performed using self-reported phenotypes and genetic data from 521,000 research participants of 23andMe. Results replicated known associations with similar effect sizes for autoimmune traits illustrating self-reported traits can be a surrogate for clinically assessed conditions. Novel associations controlling for a false...
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