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Article

D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine.

Molecular psychiatry - 1 Jan 2003

Potkin S G, Basile V S, Jin Y, Masellis M, Badri F, Keator D, Wu J C, Alva G, Carreon D T, Bunney W E, Fallon J H, Kennedy J L

Abstract excerpt

A goal of pharmacogenetics is to clarify associations between allelic variation and risk factors in psychiatric illness. We report changes in regional brain metabolism based on dopamine alleles. Treatment-resistant schizophrenic subjects were positron emission tomography scanned with 18F-fluorodeoxyglucose after 5 weeks each of placebo and clozapine treatment. Significant regional brain metabolic effects were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12556915
DOI: 10.1038/sj.mp.4001191

Genes

DRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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