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Article

Cellular resistance to bleomycin in Saccharomyces cerevisiae is not affected by changes in bleomycin hydrolase levels.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 2002

Wang Hujie, Ramotar Dindial

Abstract excerpt

Bleomycin is a glycopeptide drug that exerts potent genotoxic potential and is highly effective in the treatment of certain cancers when used in combination therapy. Unfortunately, however, tumors often develop resistance against bleomycin, and the mechanism of this resistance remains unclear. It has been postulated that bleomycin hydrolase, a protease encoded by the BLH1 gene in humans, may account for tumor...

Topics

Bleomycin
Blotting, Western
Cysteine Endopeptidases
Drug Resistance, Fungal
Gene Expression Regulation, Fungal
Immunochemistry
Mutation
Nuclear Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 12555812
DOI: 10.1139/o02-167

Genes

LAP3

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