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Article

Micronuclei frequency induced by bleomycin in human peripheral lymphocytes: correlating BLHX polymorphism with mutagen sensitivity.

Mutation research - 1 Mar 2008

Maffei Francesca, Carbone Fabio, Angelini Sabrina, Forti Giorgio Cantelli, Norppa Hannu, Hrelia Patrizia

Abstract excerpt

Mutagen sensitivity assay, by measuring chromosome damage induced by an in vitro treatment of peripheral lymphocytes with bleomycin, has been proposed as a biomarker for assessing cancer susceptibility. Recently, a single nucleotide polymorphism (SNP A1450G) of the gene for bleomycin hydrolase (BLHX), a specific neutral cysteine protease able to metabolise bleomycin, was proposed as a plausible candidate to...

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PMID: 18082847
DOI: 10.1016/j.mrfmmm.2007.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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