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Pleiotrophic cellular deficiencies conferred by the blm5-1 mutation of Saccharomyces cerevisiae.

Cellular and molecular biology (Noisy-le-Grand, France) - 1 Nov 2003

Martinez M, Pramanik A, McKoy J, Robert K, Moore C W

Abstract excerpt

Mutational alteration of the BLM5 gene of the model eukaryote, Saccharomyces cerevisiae, confers extreme hypersensitivities to lethal effects of ionizing radiation, anticancer bleomycins and structurally-related phleomycins. Additional properties conferred by the blm5-1 mutation in haploid and diploid strains were investigated for the current report. Only one copy of blm5-1 together with the normal BLM5 allele...

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PMID: 14682386

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