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Article

Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.

Structure (London, England : 1993) - 15 Jun 1999

O'Farrell P A, Gonzalez F, Zheng W, Johnston S A, Joshua-Tor L

Abstract excerpt

BACKGROUND: Bleomycin hydrolase (BH) is a cysteine protease that is found in all tissues in mammals as well as in many other eukaryotes and prokaryotes. Although its conserved cellular function is as yet unknown, human bleomycin hydrolase (hBH) has clinical significance in that it is thought to be the major cause of tumor cell resistance to bleomycin chemotherapy. In addition, it has been reported that an allelic...

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Identifiers

PMID: 10404591
DOI: 10.1016/s0969-2126(99)80083-5

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