The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.

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Article

The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.

Cancer research - 15 Aug 1991

Giaccia A J, Lewis A D, Denko N C, Cholon A, Evans J W, Waldren C A, Stamato T D, Brown J M

Abstract excerpt

As a means to understand the fundamental mechanisms of bleomycin cell killing, we previously isolated 19 bleomycin-sensitive mutants which represent at least six genetically distinct complementation groups (T.D. Stamato, B. Peters, P. Patil, N. Denko, R. Weinstein, and A. Giaccia. Cancer Res., 47: 1588-1592, 1987). One class of mutants represented by the cell line BL-10 displays only hypersensitivity to killing...

Topics

Animals
Bleomycin
Cell Line
Cell Survival
Chromosome Banding
Chromosomes, Human, Pair 6
Clone Cells
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genetic Complementation Test

Genetic Variation

Glutathione Transferase

Humans

Hybrid Cells

Ovary

Source

Open in PubMed

Identifiers

PMID: 1714344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1714344-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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