Article
Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014
Hefetz-Sela Simona, Stein Ilan, Klieger Yair, Porat Rinnat, Sade-Feldman Moshe, Zreik Farid, Nagler Arnon, Pappo Orit, Quagliata Luca, Dazert Eva, Eferl Robert, Terracciano Luigi, Wagner Erwin F, Ben-Neriah Yinon, Baniyash Michal, Pikarsky Eli
Abstract excerpt
The inflamed tumor microenvironment plays a critical role in tumorigenesis. However, the mechanisms through which immune cells, particularly macrophages, promote tumorigenesis have only been partially elucidated, and the full scope of signaling pathways supplying macrophages with protumorigenic phenotypes still remain largely unknown. Here we report that germ-line absence of c-Jun N-terminal phosphorylation at...
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