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Article

A more efficient Big Blue protocol improves transgene rescue and accuracy in a adduct and mutation measurement.

Mutation research - 25 Jul 2002

Bielas Jason H

Abstract excerpt

Transgenic mutational systems have provided researchers with an invaluable tool, allowing the measurement of both spontaneous and induced mutations. The Big Blue transgenic rodent mutagenesis system developed by Stratagene (La Jolla, CA) uses a lambda shuttle vector carrying lacI as the mutational target gene. A common criticism of the Big Blue system is that it relies on visual screening to detect mutants rather...

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PMID: 12113761
DOI: 10.1016/s1383-5718(02)00054-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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