Article
An estimator of the mutant frequency in assays using transgenic animals.
Mutation research - 15 Mar 1999
Delongchamp R R, Malling H V, Chen J B, Heflich R H
Abstract excerpt
The Poisson distribution is a fundamental probability model for count data, and is a natural model for the observed plaque counts in mutation assays using animals with lambda or PhiX174 transgenes. The Poisson likelihood for observed counts is a function of the mutant fraction, and it is straightforward to derive the associated maximum likelihood estimate of the mutant fraction and its variance. The estimate is...
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