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Article

Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2003

Zeitz Ute, Weber Karin, Soegiarto Desi W, Wolf Eckhard, Balling Rudi, Erben Reinhold G

Abstract excerpt

It was the aim of this study to further explore the functional role of vitamin D in the endocrine pancreas. By gene targeting, we have recently generated mice in which a lacZ reporter gene is driven by the endogenous vitamin D receptor (VDR) promoter. These mice express a functionally inactive mutant VDR. Pancreatic islets but not exocrine pancreas cells showed strong lacZ reporter gene expression in mutant mice....

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Source

Identifiers

PMID: 12551842
DOI: 10.1096/fj.02-0424fje

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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