Article
Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice.
Pancreas - 1 Apr 2002
Takiguchi Soichi, Suzuki Shinji, Sato Yuko, Kanai Setsuko, Miyasaka Kyoko, Jimi Atsuo, Shinozaki Hirotsugu, Takata Yutaka, Funakoshi Akihiro, Kono Akira, Minowa Osamu, Kobayashi Tomoko, Noda Tetsuo
Abstract excerpt
INTRODUCTION: The cholecystokinin (CCK) family of peptides and receptors is present throughout the brain and gastrointestinal tract. The CCK receptors can be pharmacologically subdivided into two subtypes: CCK-A and CCK-B. CCK-A receptor is enriched in the pancreas of mice. AIMS: To determine pancreatic functions in a CCK-A receptor deficient mouse mutant generated by gene targeting in embryonic stem cells. The...
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