Article
Replication status as a possible marker for genomic instability in cells originating from genotypes with balanced rearrangements.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Jan 2001
Amiel A, Levi E, Reish O, Sharony R, Fejgin M D
Abstract excerpt
Most allelic pairs of DNA replicate synchronously during the S phase of the cell cycle. However, some genes frequently replicate asynchronously, i.e. genes on the X chromosome and imprinted genes. Earlier studies demonstrated an asynchronous pattern of replication in some precancerous and invasive squamous carcinoma of the cervix as well as in multiple myeloma. A high rate of asynchronous pattern was found in:...
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