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Article

Temporal differences in replication timing of homologous loci in malignant cells derived from CML and lymphoma patients.

Genes, chromosomes & cancer - 1 Jul 1998

Amiel A, Litmanovitch T, Lishner M, Mor A, Gaber E, Tangi I, Fejgin M, Avivi L

Abstract excerpt

A close association usually exists between replication timing of a given locus and its transcriptional activity: expressed loci replicate early whereas silent ones replicate late. Accordingly, alleles that show concomitant expression replicate synchronously, while those displaying an allele-speci...

Topics

Alleles
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
DNA Replication
DNA, Neoplasm
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphoma
Sequence Homology, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 9624534
DOI: 10.1002/(sici)1098-2264(199807)22:3<225::aid-gcc8>3.0.co;2-y

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9624534-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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