Article
Temporal differences in replication timing of homologous loci in malignant cells derived from CML and lymphoma patients.
Genes, chromosomes & cancer - 1 Jul 1998
Amiel A, Litmanovitch T, Lishner M, Mor A, Gaber E, Tangi I, Fejgin M, Avivi L
Abstract excerpt
A close association usually exists between replication timing of a given locus and its transcriptional activity: expressed loci replicate early whereas silent ones replicate late. Accordingly, alleles that show concomitant expression replicate synchronously, while those displaying an allele-specific mode of expression show temporal differences in their replication timing, i.e., they replicate asynchronously. We...
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