Article
Trait-to-gene: a computational method for predicting the function of uncharacterized genes.
Current biology : CB - 21 Jan 2003
Levesque Mitchell, Shasha Dennis, Kim Wook, Surette Michael G, Benfey Philip N
Abstract excerpt
The function of unknown genes is often inferred from comparisons to well-characterized homologs. In this paper, we show that, even if all of the homologs of a gene are unannotated, its function may be deduced through phylogenetic profiling. We have designed a series of algorithms that make functional predictions of genes based on orthology and set theory, but our approach to predicting gene function requires no...
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