Essential bacterial functions encoded by gene pairs.

doi:10.1128/JB.01381-06

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Article

Essential bacterial functions encoded by gene pairs.

Journal of bacteriology - 1 Jan 2007

Thomaides Helena B, Davison Ella J, Burston Lisa, Johnson Hazel, Brown David R, Hunt Alison C, Errington Jeffery, Czaplewski Lloyd

Abstract excerpt

To address the need for new antibacterials, a number of bacterial genomes have been systematically disrupted to identify essential genes. Such programs have focused on the disruption of single genes and may have missed functions encoded by gene pairs or multiple genes. In this work, we hypothesized that we could predict the identity of pairs of proteins within one organism that have the same function. We...

Topics

Amino Acid Sequence
Bacillus subtilis
Bacterial Proteins
Computational Biology
Gene Deletion
Gene Duplication
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genes, Duplicate
Genes, Essential
Genome, Bacterial
Molecular Sequence Data
Mutation
Sequence Alignment

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Identifiers

PMID: 17114254
DOI: 10.1128/JB.01381-06
PMCID: PMC1797375

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