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Article

A cross-genomic approach for systematic mapping of phenotypic traits to genes.

Genome research - 1 Jan 2004

Jim Kam, Parmar Kush, Singh Mona, Tavazoie Saeed

Abstract excerpt

We present a computational method for de novo identification of gene function using only cross-organismal distribution of phenotypic traits. Our approach assumes that proteins necessary for a set of phenotypic traits are preferentially conserved among organisms that share those traits. This method combines organism-to-phenotype associations,along with phylogenetic profiles,to identify proteins that have high...

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Identifiers

PMID: 14707173
DOI: 10.1101/gr.1586704
PMCID: PMC314287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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