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Article

Quantitative assessment of protein function prediction from metagenomics shotgun sequences.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2007

Harrington E D, Singh A H, Doerks T, Letunic I, von Mering C, Jensen L J, Raes J, Bork P

Abstract excerpt

To assess the potential of protein function prediction in environmental genomics data, we analyzed shotgun sequences from four diverse and complex habitats. Using homology searches as well as customized gene neighborhood methods that incorporate intergenic and evolutionary distances, we inferred specific functions for 76% of the 1.4 million predicted ORFs in these samples (83% when nonspecific functions are...

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Identifiers

PMID: 17717083
DOI: 10.1073/pnas.0702636104
PMCID: PMC1955820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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