Article
Improving the specificity of high-throughput ortholog prediction.
BMC bioinformatics - 28 May 2006
Fulton Debra L, Li Yvonne Y, Laird Matthew R, Horsman Benjamin G S, Roche Fiona M, Brinkman Fiona S L
Abstract excerpt
BACKGROUND: Orthologs (genes that have diverged after a speciation event) tend to have similar function, and so their prediction has become an important component of comparative genomics and genome annotation. The gold standard phylogenetic analysis approach of comparing available organismal phylogeny to gene phylogeny is not easily automated for genome-wide analysis; therefore, ortholog prediction for large...
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