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Article

Orthologous transcription factors in bacteria have different functions and regulate different genes.

PLoS computational biology - 1 Sept 2007

Price Morgan N, Dehal Paramvir S, Arkin Adam P

Abstract excerpt

Transcription factors (TFs) form large paralogous gene families and have complex evolutionary histories. Here, we ask whether putative orthologs of TFs, from bidirectional best BLAST hits (BBHs), are evolutionary orthologs with conserved functions. We show that BBHs of TFs from distantly related bacteria are usually not evolutionary orthologs. Furthermore, the false orthologs usually respond to different signals...

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Share to Bacterial Proteins
Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene Expression Regulation, Bacterial

Share to Regulatory Sequences, Nucleic Acid

Share to Structure-Activity Relationship

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Identifiers

PMID: 17845071
DOI: 10.1371/journal.pcbi.0030175
PMCID: PMC1971122

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