Article
Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.
The Journal of biological chemistry - 17 Oct 2003
Oishi Katsutaka, Miyazaki Koyomi, Kadota Koji, Kikuno Reiko, Nagase Takahiro, Atsumi Gen-ichi, Ohkura Naoki, Azama Takashi, Mesaki Miho, Yukimasa Shima, Kobayashi Hisato, Iitaka Chisato, Umehara Takashi, Horikoshi Masami, Kudo Takashi, Shimizu Yoshihisa, Yano Masahiko, Monden Morito, Machida Kazuhiko, Matsuda Juzo, Horie Shuichi, Todo Takeshi, Ishida Norio
Abstract excerpt
CLOCK is a positive component of a transcription/translation-based negative feedback loop of the central circadian oscillator in the suprachiasmatic nucleus in mammals. To examine CLOCK-regulated circadian transcription in peripheral tissues, we performed microarray analyses using liver RNA isolated from Clock mutant mice. We also compared expression profiles with those of Cryptochromes (Cry1 and Cry2) double...
Topics
- Amino Acid Motifs
- Animals
- Base Sequence
- Binding Sites
- Blotting, Northern
- CLOCK Proteins
- Circadian Rhythm
- Fatty Acids
- Genome