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DNA hypermethylation regulates the expression of members of the Mu-class glutathione <i>S</i>-transferases and glutathione peroxidases in Barrett’s adenocarcinoma

29 Jul 2008

Abstract excerpt

BACKGROUND: The accumulation of reactive oxygen species and subsequent oxidative DNA damage underlie the development of Barrett's oesophagus (BO) and its progression to Barrett's dysplasia (BD) and adenocarcinoma (BAC). METHODS: The promoter regions of 23 genes of the glutathione S-transferase (GST) and glutathione peroxidase (GPX) families were systematically analysed. Quantitative bisulfite pyrosequencing,...

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Share to Epigenetics and DNA Methylation
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PMID: 18664505
DOI: 10.1136/gut.2007.146290

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