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Article

Toll-like receptor 4-positive macrophages protect mice from Pasteurella pneumotropica-induced pneumonia.

Infection and immunity - 1 Feb 2003

Hart Marcia L, Mosier Derek A, Chapes Stephen K

Abstract excerpt

This study investigates Toll-like receptor 4 (TLR4)-positive macrophages in early recognition and clearance of pulmonary bacteria. TLR4 is a trans-membrane receptor that is the primary recognition molecule for lipopolysaccharide of gram-negative bacteria. The TLR4(Lps-del) mouse strains C57BL10/ScN (B10) and STOCK Abb(tm1) TLR4(Lps-del) Slc11a1(s)(B10 x C2D) are susceptible to pulmonary infections and develop...

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Topics

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Share to Adoptive Transfer
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pneumonia, Bacterial

Share to Receptors, Cell Surface

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Source

Open in PubMed Open full text

Identifiers

PMID: 12540543
DOI: 10.1128/IAI.71.2.663-670.2003
PMCID: PMC145384

Genes

TLR4
MIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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