Article
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Zhang Jin, Asin-Cayuela Jordi, Fish Jennifer, Michikawa Yuichi, Bonafe Massimiliano, Olivieri Fabiola, Passarino Giuseppe, De Benedictis Giovanna, Franceschi Claudio, Attardi Giuseppe
Abstract excerpt
The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated. Large-scale screening of the mtDNA main control region in leukocytes from subjects of an Italian population revealed a homoplasmic C150T transition near an origin of heavy mtDNA-strand synthesis in approximately 17% of 52 subjects 99-106 years old, but,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.